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Andorogynus is a top-down shoot-em-up. The player controls the titular hero(ine), shooting at constantly attacking enemies. Unlike in most games of the type, the screen scrolls down rather than up. The protagonist is equipped with a default single shot and has protective orbs revolving around that damage nearby enemies. The weapon can be enhanced (rapid fire, three-way fire, etc.) by collecting randomly descending power-ups. The player controls the male incarnation of the protagonist initially, but later switches to the female one.